About BigHat

We are an early-stage biotechnology company in the Bay Area

Our Team

Mark DePristo, PhD

CEO & Co-Founder

Mark is a leader in applying computational and statistical techniques to biomedical challenges in genomics and biochemistry. Before BigHat, he founded the Genomics team in Google Brain, was VP of Informatics at SynapDx, and was Co-Director of Medical and Population Genetics at the Broad Institute. He has a BA in CS and Math from Northwestern, a PhD in Biochemistry from Cambridge as a Marshall Scholar, and was a Damon Runyon Cancer Research Fellow at Harvard. Dr. DePristo's academic articles are widely published with more than 72,000 citations.

Peyton Greenside, PhD

CSO & Co-Founder

A pioneer of deep learning applied to life science problems, Peyton has developed computational, statistical, and AI/ML techniques to model, understand, and optimize biological sequences in academia and industry. Peyton was an inaugural Schmidt Science Fellow, a computational biologist at the Broad Institute, a scientific founder of Valis, and holds a PhD from Stanford University (Accel Innovation Scholar), an MPhil in Computational Biology from Cambridge University (Herchel Smith Scholar), and a BA in Applied Math from Harvard.

​Theresa Tribble

Founding Advisor

Theresa is a C-suite leader with a passion for cutting-edge science and solving big problems that drive societal impact. She is an Entrepreneur in Residence (EIR) at The Engine, a venture capital firm, and the founder of Nebula Industries, a strategic consulting firm for the diagnostic and medical device industries. Before BigHat, Theresa was Chief Business Officer at EverlyWell, a direct-to-consumer diagnostic testing firm, the Life Sciences EIR at Harvard Business School, VP of Commercial Strategy at SynapDx, and a business consultant at Putnam.​

Eddie Abrams, PhD

VP of Engineering

Eddie got his PhD in Philosophy from the University of Massachusetts Amherst while running software development for Boston area start-ups. He has tackled diverse problems from full stack web development to genomics pipelines. Before BigHat he was Senior Director of Engineering at GoDaddy, where he led an organization focused on automation and security and drove the transformation to a cloud native architecture. Previously, he created a web-scale analytics pipeline to match patients with medical specialists at Kyruus and a cloud-based ML for multi-omics biomarker discovery at SynapDx.

Randall Brezski, PhD

Senior Director, Antibody Engineering

Randall has over 15 years of drug development experience advancing multiple antibody-based drugs projects into clinical development. He completed his PhD in Immunology at the University of Pennsylvania and was a Johnson and Johnson Science and Technology Fellowship at Centocor, a Principal Scientist at Janssen in the Biologics Research Department, an antibody engineer at Genentech, and Director and Head of Protein Sciences at Surrozen. Randall has authored over 30 peer reviewed publications, is an inventor on eight issued patents, and serves as an Assistant Editor for the journal MAbs.

Ryan Henrici, PhD

Infectious Disease Specialist

Ryan is an expert in emerging and re-emerging pathogens and leader in drug discovery and resistance. Ryan is also an Associate Scholar and Lecturer at the Center for Global Health at the University of Pennsylvania School of Medicine and a contributor to national policy on global health issues in the US and UK. He holds a PhD in Infectious and Tropical Diseases from the London School of Hygiene & Tropical Medicine (Marshall Scholar) and a BSc (Hons) in Biochemistry and Molecular Biology from Penn State. In 2021 Ryan will receive his MD from the Perelman School of Medicine at the University of Pennsylvania.

Jeremy Hert

Software Architect

Jeremy has spent the last decade as a full-stack engineer building software in the biomedical, healthcare, and location analytics spaces. Before joining BigHat, Jeremy was a Principal Software Engineer at the Broad Institute where he led a team to develop an open-source data repository for securely storing, searching, and sharing biomedical data. Previously he was at LevelTrigger where he worked on a range of initiatives spanning from automating ML pipelines to implementing interactive data visualizations. Prior to that he was on the analytics and ontology teams at Kyruus and supported drug discovery at Novartis, building an assay data warehouse and web-based LIMS

Ute Geigenmuller, PhD

Scientific Programs Manager

Before BigHat, Ute focused on the development of tools for the interpretation and communication of genetic analysis results. She was most recently a member of the clinical bioinformatics team at LabCorp and has previously held positions as VP of Assay Development at SynapDx and Chief Scientist at Correlagen Diagnostics. Ute received her PhD in Biochemistry from the Freie Universität Berlin, Germany, and conducted research on the biology of RNA viruses at Washington University, the Fred Hutchinson Cancer Research Center, and Stanford University before switching to human genomics.

Hassan Kane

Machine learning consultant

Hassan has over 5 years of experience developing AI systems in academic and industry settings. His industry roles include being the Lead Data Scientist at Emtropy Labs, where he builds NLP models to analyze customer service conversations, CTO of Sela where he implemented an enterprise platform for transparency in infrastructure projects. Before diving into the startup world, he studied Computer Science at MIT. As an undergraduate, Hassan co-founded the undergraduate machine intelligence community, interned at Facebook, and developed radar perception algorithms for Uber ATG. He has 4 peer-reviewed publications including work on protein representation learning.

Vivek Myers

AI/ML consultant

Vivek is an undergraduate at Stanford University studying math and computer science. He has interned at Facebook and done undergraduate research at Cornell and Stanford, focusing on active learning, multi-armed bandits, and reinforcement learning.

Annalisa Sharkey

Platform Technician

Anna graduated from the University of Rhode Island with degrees in Pharmaceutical Science and Biological Science and a master’s from Tufts University in Conservation Medicine. She has previously worked in a range of biological disciplines including immunology, virology, and environmental toxicology. Prior to BigHat, she worked at the Plum Island Foreign Animal Disease and Diagnostics Laboratory and at BioMarin. During her graduate degree, she completed two pilot studies and has been published in the National Center for Case Study Teaching in Science.

Our Advisors

Brian Kobilka, MD

Brian is Professor of Molecular and Cellular Physiology at Stanford University focused on characterizing the structure and mechanism of activation of G protein-coupled receptors (GPCRs), for which he received the 2012 Nobel Prize in Chemistry.

Greg Landes, PhD

Gregory has over 37 years of biotechnology industry experience with broad expertise in target discovery and validation, antibody and ADC drug discovery and preclinical development, molecular biology, genetics, genomics, and biochemistry. Previously, he held positions with Takeda (VP Biology/VP Discovery, Research and Preclinical Development), Lexicon Pharmaceuticals (VP, Biotherapeutics), Abgenix (VP, Product Discovery), Genzyme and Integrated Genetics.

Jacob Gardner, PhD

Jacob is an Assistant Professor of Computer and Information Science at the University of Pennsylvania. Jacob's research is in machine learning, with a focus on scalable methods for probabilistic machine learning and Bayesian optimization. Jacob co-created GPyTorch, one of the most popular OSS packages for Gaussian processes; was a Research Scientist in Uber AI Labs; and completed his Ph.D. in Computer Science at Cornell University.

Javin Oza, PhD

Javin is Assistant Professor of Chemistry and Biochemistry at California Polytechnic State University, San Luis Obispo. His research leverages cell-free protein synthesis technology and an expanded genetic code to manufacture, on-demand, previously intractable proteins and to elucidate how these proteins support the physiology of healthy and diseased cells. Before joining the faculty, Javin completed his post-doctoral training at Northwestern; he holds a Ph.D. Biochemistry from UC Santa Barbara.

Nigel Reuel, PhD

Nigel is Assistant Professor of Chemical & Biological Engineering at Iowa State University. In his lab, Nigel develops cell-free protein synthesis technologies and biosensors for biomedical and agricultural applications, with a particular emphasis on multifunctional, protein-based materials for medical, consumer, and sensor applications. Nigel is a founder of Skroot Labs, carried out biomaterials research and technology scouting at DuPont, and holds a Ph.D. in Chemical Engineering from MIT.

Pauline Jen Ryan

Pauline is a Partner at Red Sky Partners, an advisory firm in Cambridge, MA serving biotech companies and Boards in interim C-level management roles, driving corporate strategy and corporate development, and planning, executing, and completing strategic transactions. She has 30 years of experience in the biotech industry and has closed over 100 transactions during this time. Pauline was a founding member of the Biotechnology Industry Organization's Business Development Advisory Committee and launched the BIO Business Development Fundamentals course. Pauline has an MBA from the Kellogg School of Management at Northwestern University.

Stanley Lapidus

Stan is an experienced life-science entrepreneur and inventor with over 30 issued U.S. patents. He founded and led SynapDX, ​Helicos BioSciences, Exact Biosciences ($EXAS), Cytyc ($CYTC) and is a member of the Board of Directors at Glympse Bio, Binx Health, PathAI, Fractyl Biosciences, and T2 Biosystems. Stan has held academic appointments at Tufts and MIT and is a fellow of the American Institute of Medical and Biological Engineering. He received his B.S. in engineering from Cooper Union.

Our investors

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