MPO
Affinity, stability, expression and function are optimized together in every design round, not one at a time.
Internalization
Binders tuned for rapid uptake and release into target cells, maximizing payload delivery into each cell.
Multispecifics
VHH, scFv, and Fab building blocks are optimized and assembled into multispecific formats that reliably express well and behave as designed.
Paralogue Specificity
Antibodies that bind the intended target and leave its closely related family members untouched.
pH Conditionality
Binding that depends on environmental pH, unlocking tissue specificity and endolysosomal release.
AND/NOT Logic
Multispecifics that act only where two targets are present (A+B), or are blocked where a healthy-associated antigen appears (A NOT A+B).
IF-BETTER Logic
Low-affinity, high-avidity designs that engage cells overexpressing the target and spare cells with lower levels.
Developability & Cross-Reactivity
Candidates built from the start for manufacturability, stability and equivalent binding to human and primate targets.
