Careers at BigHat

BigHat is continually growing our team of exceptional antibody and protein engineers, AI/ML engineers, computational biologists, research technicians, and business development professionals with experience in therapeutic antibody development.

Roles that we are specifically recruiting for now are listed below.

BigHat offers competitive compensation and benefits packages. We pride ourselves on our team-oriented, inclusive, remote-friendly, and family-centric culture.

If you are interested in discussing opportunities at BigHat, please email careers@bighatbio.com to start a conversation.

Software Engineer - Lab Automation

About the Role: We’re seeking an exceptional, self-motivated software engineer with an automation bent to help us design and implement a laboratory device control plane including workflow protocols and data capture. Using agile, cloud-native software design patterns and a DevOps mindset, you’ll collaborate with the science and data teams to advance our efforts to:

  • Create a first-in-class workflow and data control plane for our laboratory devices.
  • Automate laboratory processes with robots to optimize for efficient, reproducible assays and reliable data capture.
  • Make data streaming from our labs as valuable and actionable as possible.
  • Continuously improve the reliability, repeatability, efficiency and visibility of all automatable lab processes. 
  • Continuously increase the scope of our automation and workflow control.
  • Tightly link experimental and machine learning platform components.
  • Nice-to-haves include: Laboratory or sensor-based devices background; experience with: Python 3, RESTful API design, AWS, RDBMS such as PostgreSQL, PyTorch or other AI/ML software or GPU programming.

Compensation will include a competitive pay package, benefits, and equity commensurate with being an early employee at a growth-oriented startup. Job title and compensation will be set based on experience, so we encourage applicants with a diverse range of experiences to apply.


About You: You have a stellar track record in both design and execution in prior engineering roles and 5+ years of hands-on software programming experience. You can communicate with engineers and non-engineers effectively and synthesize requirements and needs between lab scientists, data scientists and engineers. You thrive in a fast-paced environment helping to launch, operate and grow a high-potential startup. If you love tinkering, optimizing and diving headfirst into diverse, highly technical projects then BigHat could be the right home for you. 


Please reach out to careers@bighatbio.com to start a conversation about this role.

VP/Director of Biotherapeutics

BigHat Biosciences is seeking an exceptional individual to drive BigHat’s therapeutic antibody programs and develop an in-house pipeline that leverages the unique advantages of BigHat’s technologies. The goals and responsibilities of this position include:

  • Craft a vision for antibody discovery and development at BigHat of therapeutic programs uniquely possible using BigHat’s technologies in collaboration with other senior leaders.
  • Translate this vision into a strategic portfolio of therapeutic antibody programs with a roadmap spanning from antibody discovery through clinical development.
  • Execute on all aspects of this strategy necessary to advance our molecules into patients, from expanding teams, expertise, and technologies within BigHat to cultivating and nurturing external relationships among KOLs, partners, and clinical teams.

This role reports directly to the CSO; works closely with other executives and senior leaders; and has broad responsibilities across BigHat for overall corporate performance.


About You: 

  • A broad strategic thinker with a track record of contributing at top-tier companies in drug development or a related area and deep understanding of the underlying science (PhD).
  • Expertise in therapeutic discovery, from target selection through lead identification and all other aspects of preclinical development.
  • Able to collaboratively develop a therapeutic strategy that prioritizes clinical and commercial opportunities where BigHat’s cutting-edge scientific and technical capabilities offer a unique competitive advantage.
  • A get-it-done mentality; experience operating in a small and agile therapeutic startup.
  • Wonderful execution and communication skills to translate your strategic vision into tangible goals by managing a team to deliver on that roadmap over a long timeframe.

Compensation will include a top-shelf pay package, benefits, and equity commensurate with being on the leadership team at an early-stage, growth-oriented, family-friendly startup. 


Please reach out to careers@bighatbio.com to start a conversation about this role. 

Head of Platform Development

BigHat Biosciences is seeking an exceptional, self-motivated scientist with an engineering mindset to lead the development of BigHat’s high-throughput, automated platform for producing and characterizing antibodies. Responsibilities include:

  • Own the development and optimization of the BigHat work cell for antibody production, purification and characterization with high throughput and low cost and consumable use.
  • Lead the sourcing, onboarding, validation, and operation of cutting-edge assays to produce and characterize antibody biophysical properties (e.g. stability, solubility).
  • Lead process engineering efforts to evaluate, optimize and integrate platform components for throughput, efficiency, and cost.
  • Critically evaluate and re-design the status quo from cell-free synthesis through ex-vivo antibody characterization to accelerate BigHat’s platform capabilities
  • Collaborate closely with BigHat executives, AI/ML, and other team members to ensure a tight linkage between the experimental and machine learning platform components.
  • Nice-to-haves include antibody or protein engineering background; experience developing cell-free protein extracts, programming skills, automation experience


Compensation will include a competitive pay package, benefits, and equity commensurate with being an early employee at a growth-oriented startup. Job title and compensation will be set based on experience, so we encourage applicants with a diverse range of experiences to apply.


About You: You have a stellar track record at top-tier institutions or companies, a strong scientific background (PhD) and publication record in molecular biology or biochemistry, fluency with protein expression, purification, and characterization techniques, and 3+ years of hands-on technical development experience such as assay development and process engineering; excellent communication skills; thrives in a fast-paced environment helping to launch, operate and grow a high-potential startup. If you love tinkering, optimizing and diving headfirst into diverse, highly technical projects then BigHat could be the right home for you. 


Please reach out to careers@bighatbio.com to start a conversation about this role.