December 14, 2020
BigHat is delighted to welcome Steve Doberstein to the BigHat advisory team! Steve is an expert in protein engineering with over 20 years of experience in the design and development of antibody, cytokine, and fusion protein drugs. Steve joins us most recently from Nektar Therapeutics where he was Chief R&D Officer and Chief Scientist for ten years and led all aspects of discovery research. Before that he was VP Research at innovative antibody developers XOMA, Five Prime Therapeutics, and Xencor where he played a pivotal role in bringing multiple product candidates through to IND in diabetes, oncology, autoimmune diseases. Steve holds a PhD in Cell Biology from Johns Hopkins University School of Medicine and did his postdoctoral training at UC Berkeley. Steve sits on the Board of Directors of Dicerna, and the Biotechnology Advisory Board of the University of Delaware.
Read more at the BigHat team at https://www.bighatbio.com/about.
November 18, 2020
October 1, 2020
BigHat Biosciences received a Phase I SBIR award from NIST (National Institute of Standards and Technology) to apply its AI-driven platform to rapidly identify high-yield expression vectors for therapeutic antibody production.
BigHat’s Chief Scientific Officer, Dr. Peyton Greenside, noted, “We are honored that NIST sees the potential for our approach. This Phase I study will demonstrate that BigHat’s platform can design novel and improved DNA templates by querying only a tiny fraction of candidate sequences in a massive search space.”
The Phase I SBIR grant aims to increase protein production by jointly optimizing a 30 base pair DNA sequence involving the expression cassette and start of the protein coding sequence through tight coupling of computational and experimental evaluation on the BigHat platform. Sequences longer than ~10 base pairs have been historically intractable to search effectively because the search space is simply too large for comprehensive experimental exploration.
“We started BigHat Biosciences because we believe that AI/ML-powered molecular engineering will allow us to design biotherapeutics inaccessible to traditional approaches,” shared CEO Mark DePristo, PhD. “Our work with NIST will help BigHat benchmark and further improve our technologies for data-driven antibody design.
About BigHat Biosciences
BigHat Biosciences is an early-stage Bay Area startup reimagining antibody discovery and engineering to create better antibodies faster and undertake novel designs far beyond what's possible today. BigHat designs antibodies using an agile, multi-objective, and data-driven platform that integrates a high-speed wet lab with AI and machine learning. Founded in 2019, BigHat Biosciences counts among its founders, employees, and advisors world-leading experts in machine learning and artificial intelligence, computational biology, software engineering, and drug development. BigHat’s investors include 8VC, AME Cloud Ventures, and Innovation Endeavors. Learn more at www.bighatbio.com.
NIST (National Institute of Standards and Technology), a nonregulatory agency of the U.S. Department of Commerce, promotes U.S. innovation and industrial competitiveness by advancing measurement science, standards and technology in ways that enhance economic security and improve our quality of life. To learn more about NIST, visit NIST.gov.
September 15, 2020
Amgen and MBC BioLabs announced today that BigHat Biosciences has been awarded a 2020 Amgen Golden Ticket to MBC BioLabs.
BigHat was chosen by a team of scientific leaders who evaluated the strength and novelty of our scientific rationale, subject matter expertise, and business plan viability.
Flavius Martin, vice president of Oncology, Inflammation and Site Head at Amgen South San Francisco, said "BigHat Biosciences [...] is working on promising early-stage innovation that address serious illnesses such as cancer, autoimmune diseases, infectious diseases, and others [...] We are happy to support their scientific efforts as they tackle complex research challenges that potentially address critical unmet medical needs for patients. Congratulations to both companies and their scientific entrepreneurs.”
BigHat will use Amgen's support for our facility at MBC BioLabs and access to their biologics R&D group to help accelerate its mission to radically improve antibody design using the latest techniques in machine learning and synthetic biology.
BigHat joins Golden Ticket winners Trilo Therapeutics (2020), Regencor and Nitrome Biosciences (2019), Delve Therapeutics and Mitokinin (2018), Darmiyan and Enable Biosciences (2017), and Mission Bio and SiteOne Therapeutics.
August 12, 2020
BigHat co-founder Peyton Greenside joins a panel discussion, along other leaders from Silicon Valley Bank, Civilization Ventures, Pivotal Bioventure Partners, BioRock Ventures, to discuss: Is this The Lost Year for Startups, or the Year of Greatest Opportunity?
2020 has brought renewed focus to the promise of biotech and the ability of novel therapeutics to meet society's urgent needs. It has also highlighted the current limits of science, the fragility of our health care system, and the long process from R&D to market for new drugs. What does this all mean for you and your startup, and how will you thrive amidst the uncertainty? Our expert VC/CEO panelists weigh in with concrete advice and stories from the trenches.
July 18, 2020
BigHat founder Peyton Greenside and BigHat consultant Vivek Myers presented their work A Hierarchical Approach to Scaling Batch Active Search Over Structured Data at the ICML Workshop on Real World Experiment Design and Active Learning. The method enables efficient, large-batch search over a structured set of protein or DNA sequences by combining deep representation learning with a hierarchical search strategy. It balances broad exploration over unobserved sequence space with more greedy local search where promising sequences have been identified. These innovations were possible by taking advantage of the natural emergent structure in a large corpus of related biological sequences to help guide experimental design in a high-throughput setting.
June 9, 2020
BigHat founder and CEO Mark DePristo spoke at the European Society for Human Genetics 2020 Conference. Watch the talk A Guide to Deep Learning in Healthcare on BigHat's YouTube channel or review just the slides.
April 30, 2020
BigHat founder Peyton Greenside joins Insitro team member to lead working session with Stanford's Accel Innovation Scholars on building and leading interdisciplinary teams.
December 4, 2019
BigHat founder Peyton Greenside helps select the best poster at the Cell Free Systems Conference in Boston, MA.
November 11, 2019
BigHat founder Peyton Greenside moderates Innovation Endeavors' Deep Life Salon panel between biotech founders and pharmaceutical partners from Novozymes and Novo Nordisk on commercializing research.
October 30, 2019